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Title:

The Normal Range of Baseline Tryptase Should Be 1 to 15 ng/mL and Covers Healthy Individuals With HαT.

Document type:
Journal Article; Review; Research Support, N.I.H., Intramural; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Valent, Peter; Hoermann, Gregor; Bonadonna, Patrizia; Hartmann, Karin; Sperr, Wolfgang R; Broesby-Olsen, Sigurd; Brockow, Knut; Niedoszytko, Marek; Hermine, Olivier; Chantran, Yannick; Butterfield, Joseph H; Greiner, Georg; Carter, Melody C; Sabato, Vito; Radia, Deepti H; Siebenhaar, Frank; Triggiani, Massimo; Gülen, Theo; Alvarez-Twose, Ivan; Staudinger, Thomas; Traby, Ludwig; Sotlar, Karl; Reiter, Andreas; Horny, Hans-Peter; Orfao, Alberto; Galli, Stephen J; Schwartz, Lawrence B; Lyons, Jonath...     »
Abstract:
Physiological levels of basal serum tryptase vary among healthy individuals, depending on the numbers of mast cells, basal secretion rate, copy numbers of the TPSAB1 gene encoding alpha tryptase, and renal function. Recently, there has been a growing debate about the normal range of tryptase because individuals with the hereditary alpha tryptasemia (HαT) trait may or may not be symptomatic, and if symptomatic, uncertainty exists as to whether this trait directly causes clinical phenotypes or agg...     »
Journal title abbreviation:
J Allergy Clin Immunol Pract
Year:
2023
Journal volume:
11
Journal issue:
10
Pages contribution:
3010-3020
Fulltext / DOI:
doi:10.1016/j.jaip.2023.08.008
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37572755
Print-ISSN:
2213-2198
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie (Prof. Biedermann)
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