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Document type:
Journal Article; Review
Author(s):
Sitaru, Sebastian; Budke, Agnes; Bertini, Riccardo; Sperandio, Markus
Title:
Therapeutic inhibition of CXCR1/2: where do we stand?
Abstract:
Mounting experimental evidence from in vitro and in vivo animal studies points to an essential role of the CXCL8-CXCR1/2 axis in neutrophils in the pathophysiology of inflammatory and autoimmune diseases. In addition, the pathogenetic involvement of neutrophils and the CXCL8-CXCR1/2 axis in cancer progression and metastasis is increasingly recognized. Consequently, therapeutic targeting of CXCR1/2 or CXCL8 has been intensively investigated in recent years using a wide array of in vitro and anima...     »
Journal title abbreviation:
Intern Emerg Med
Year:
2023
Journal volume:
18
Journal issue:
6
Pages contribution:
1647-1664
Fulltext / DOI:
doi:10.1007/s11739-023-03309-5
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37249756
Print-ISSN:
1828-0447
TUM Institution:
594; Klinik und Poliklinik für Dermatologie und Allergologie (Prof. Biedermann)
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