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Title:

N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kα inhibition in breast cancer.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Auf der Maur, Priska; Trefny, Marcel P; Baumann, Zora; Vulin, Milica; Correia, Ana Luisa; Diepenbruck, Maren; Kramer, Nicolas; Volkmann, Katrin; Preca, Bogdan-Tiberius; Ramos, Pedro; Leroy, Cedric; Eichlisberger, Tobias; Buczak, Katarzyna; Zilli, Federica; Okamoto, Ryoko; Rad, Roland; Jensen, Michael Rugaard; Fritsch, Christine; Zippelius, Alfred; Stadler, Michael B; Bentires-Alj, Mohamed
Abstract:
A genome-wide PiggyBac transposon-mediated screen and a resistance screen in a PIK3CAH1047R-mutated murine tumor model reveal NF1 loss in mammary tumors resistant to the phosphatidylinositol 3-kinase α (PI3Kα)-selective inhibitor alpelisib. Depletion of NF1 in PIK3CAH1047R breast cancer cell lines and a patient-derived organoid model shows that NF1 loss reduces sensitivity to PI3Kα inhibition and correlates with enhanced glycolysis and lower levels of reactive oxygen species (ROS). Unexpectedly,...     »
Journal title abbreviation:
Cell Rep Med
Year:
2023
Journal volume:
4
Journal issue:
4
Fulltext / DOI:
doi:10.1016/j.xcrm.2023.101002
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37044095
TUM Institution:
Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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