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Title:

Osteoprogenitor SFRP1 prevents exhaustion of hematopoietic stem cells via PP2A-PR72/130-mediated regulation of p300.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Hettler, Franziska; Schreck, Christina; Marquez, Sandra Romero; Engleitner, Thomas; Vilne, Baiba; Landspersky, Theresa; Weidner, Heike; Hausinger, Renate; Mishra, Ritu; Oellinger, Rupert; Rauner, Martina; Naumann, Ronald; Peschel, Christian; Bassermann, Florian; Rad, Roland; Istvanffy, Rouzanna; Oostendorp, Robert A J
Abstract:
Remodeling of the bone marrow microenvironment in chronic inflammation and in aging reduces hematopoietic stem cell (HSC) function. To assess the mechanisms of this functional decline of HSC and find strategies to counteract it, we established a model in which the Sfrp1 gene was deleted in Osterix+ osteolineage cells (OS1Δ/Δ mice). HSC from these mice showed severely diminished repopulating activity with associated DNA damage, enriched expression of the reactive oxygen species pathway and reduce...     »
Journal title abbreviation:
Haematologica
Year:
2023
Journal volume:
108
Journal issue:
2
Pages contribution:
490-501
Fulltext / DOI:
doi:10.3324/haematol.2022.280760
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35950533
Print-ISSN:
0390-6078
TUM Institution:
Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie; Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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