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Dokumenttyp:
Article; Journal Article
Autor(en):
Wagner, Julian U G; Tombor, Lukas S; Malacarne, Pedro Felipe; Kettenhausen, Lisa-Maria; Panthel, Josefine; Kujundzic, Haris; Manickam, Nivethitha; Schmitz, Katja; Cipca, Maria; Stilz, Kathrin A; Fischer, Ariane; Muhly-Reinholz, Marion; Abplanalp, Wesley T; John, David; Mohanta, Sarajo K; Weber, Christian; Habenicht, Andreas J R; Buchmann, Giulia K; Angendohr, Stephan; Amin, Ehsan; Scherschel, Katharina; Klöcker, Nikolaj; Kelm, Malte; Schüttler, Dominik; Clauss, Sebastian; Günther, Stefan; Boettg...     »
Titel:
Aging impairs the neurovascular interface in the heart.
Abstract:
Aging is a major risk factor for impaired cardiovascular health. Because the aging myocardium is characterized by microcirculatory dysfunction, and because nerves align with vessels, we assessed the impact of aging on the cardiac neurovascular interface. We report that aging reduces nerve density in the ventricle and dysregulates vascular-derived neuroregulatory genes. Aging down-regulates microRNA 145 (miR-145) and derepresses the neurorepulsive factor semaphorin-3A. miR-145 deletion, which inc...     »
Zeitschriftentitel:
Science
Jahr:
2023
Band / Volume:
381
Heft / Issue:
6660
Seitenangaben Beitrag:
897-906
Volltext / DOI:
doi:10.1126/science.ade4961
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37616346
Print-ISSN:
0036-8075
TUM Einrichtung:
1121; 594; 606; Klinik und Poliklinik für Innere Medizin I, Kardiologie (Prof. Laugwitz)
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