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Titel:

Initial evaluation of [18F]-FACBC for PET imaging of multiple myeloma.

Dokumenttyp:
Article; Journal Article
Autor(en):
Morath, Volker; Heider, Michael; Mittelhäuser, Markus; Rolbieski, Hannes; Stroh, Jacob; Calais, Jérémie; Eiber, Matthias; Bassermann, Florian; Weber, Wolfgang A
Abstract:
RATIONALE: Multiple myeloma (MM) cells synthesize large amounts of paraproteins, making radiolabeled amino acids promising candidates for PET imaging of MM patients. METHODS: We compare tumor uptake of the two amino acid analogs [18F]-fluoroethyltyrosine and [18F]-FACBC in a MM xenograft model and show the feasibility of PET imaging with [18F]-FACBC in a MM patient. RESULTS: Preclinically [18F]-FACBC showed superior performance, mainly due to the uptake via the ASC-system. In a subsequent proof-...     »
Zeitschriftentitel:
EJNMMI Res
Jahr:
2022
Band / Volume:
12
Heft / Issue:
1
Volltext / DOI:
doi:10.1186/s13550-022-00876-0
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35099620
Print-ISSN:
2191-219X
TUM Einrichtung:
Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie; Klinik und Poliklinik für Nuklearmedizin
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