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- Title:
Comparative Analysis of Morphological and Functional Effects of 225Ac- and 177Lu-PSMA Radioligand Therapies (RLTs) on Salivary Glands.
- Document type:
- Comparative Study; Journal Article
- Author(s):
- Feuerecker, Benedikt; Gafita, Andrei; Langbein, Thomas; Tauber, Robert; Seidl, Christof; Bruchertseifer, Frank; Gschwendt, Jürgen E; Weber, Wolfgang A; D'Alessandria, Calogero; Morgenstern, Alfred; Eiber, Matthias
- Abstract:
- Most Prostate Specific Membrane Antigens (PSMAs) targeting small molecules accumulate in the salivary glands (SGs), raising concerns about SG toxicity, especially after repeated therapies or therapy with 225Ac-labeled ligands. SG toxicity is assessed clinically by the severity of patient-reported xerostomia, but this parameter can be challenging to objectively quantify. Therefore, we explored the feasibility of using SG volume as a biomarker for toxicity. In 21 patients with late-stage metastatic resistant prostate cancer (mCRPC), the PSMA volume and ligand uptake of SG were analyzed retrospectively before and after two cycles of 177Lu-PSMA (LuPSMA; cohort A) and before and after one cycle of 225Ac-PSMA-617 (AcPSMA, cohort B). Mean Volume-SG in cohort A was 59 ± 13 vs. 54 ± 16 mL (-10%, p = 0.4), and in cohort B, it was 50 ± 13 vs. 40 ± 11 mL (-20%, p = 0.007), respectively. A statistically significant decrease in the activity concentration in the SG was only observed in group B (SUVmean: 9.2 ± 2.8 vs. 5.3 ± 1.8, p < 0.0001; vs. A: SUVmean: 11.2 ± 3.3 vs. 11.1 ± 3.5, p = 0.8). SG volume and PSMA-ligand uptake are promising markers to monitor the SG toxicity after a PSMA RLT.
- Journal title abbreviation:
- Int J Mol Sci
- Year:
- 2023
- Journal volume:
- 24
- Journal issue:
- 23
- Fulltext / DOI:
- doi:10.3390/ijms242316845
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/38069166
- Print-ISSN:
- 1422-0067
- TUM Institution:
- 595; Klinik und Poliklinik für Nuklearmedizin (Prof. Weber); Klinik und Poliklinik für Urologie (Prof. Gschwend)
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