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Title:

Skeletal muscle and intermuscular adipose tissue gene expression profiling identifies new biomarkers with prognostic significance for insulin resistance progression and intervention response.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Lutter, Dominik; Sachs, Stephan; Walter, Marc; Kerege, Anna; Perreault, Leigh; Kahn, Darcy E; Wolide, Amare D; Kleinert, Maximilian; Bergman, Bryan C; Hofmann, Susanna M
Abstract:
AIMS/HYPOTHESIS: Although insulin resistance often leads to type 2 diabetes mellitus, its early stages are often unrecognised, thus reducing the probability of successful prevention and intervention. Moreover, treatment efficacy is affected by the genetics of the individual. We used gene expression profiles from a cross-sectional study to identify potential candidate genes for the prediction of diabetes risk and intervention response. METHODS: Using a multivariate regression model, we linked gen...     »
Journal title abbreviation:
Diabetologia
Year:
2023
Journal volume:
66
Journal issue:
5
Pages contribution:
873-883
Fulltext / DOI:
doi:10.1007/s00125-023-05874-y
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36790478
Print-ISSN:
0012-186X
TUM Institution:
602; Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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