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Document type:
Journal Article
Author(s):
Plambeck, Marten; Kazeroonian, Atefeh; Loeffler, Dirk; Kretschmer, Lorenz; Salinno, Ciro; Schroeder, Timm; Busch, Dirk H; Flossdorf, Michael; Buchholz, Veit R
Title:
Heritable changes in division speed accompany the diversification of single T cell fate.
Abstract:
Rapid clonal expansion of antigen-specific T cells is a fundamental feature of adaptive immune responses. It enables the outgrowth of an individual T cell into thousands of clonal descendants that diversify into short-lived effectors and long-lived memory cells. Clonal expansion is thought to be programmed upon priming of a single naive T cell and then executed by homogenously fast divisions of all of its descendants. However, the actual speed of cell divisions in such an emerging "T cell family...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2022
Journal volume:
119
Journal issue:
9
Fulltext / DOI:
doi:10.1073/pnas.2116260119
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35217611
Print-ISSN:
0027-8424
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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