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Title:

Knockout of αβ but not γδ T cells in chickens is associated with high cytotoxicity and deficiency of regulatory and helper T cells

Document type:
Zeitschriftenaufsatz
Author(s):
Theresa von Heyl Romina Klinger Dorothea Aumann Christian Zenner Mohanned Alhussien Antonina Schlickenrieder Kamila Lengyel Hanna-Kaisa Vikkula Teresa Mittermair Hicham Sid Benjamin Schusser
Abstract:
The availability of genetically modified mice has facilitated the study of mammalian T cells. No model has yet been developed to study these cells in chicken, an important livestock species with a high availability of γδ T cells. To investigate the role of γδ and αβ T cell populations in birds, we generated chickens lacking these T cell populations. This was achieved by genomic deletion of the constant region of the T cell receptor γ or αβ chain, leading to a complete loss of either γδ or αβ T c...     »
Journal title:
biorxiv
Year:
2023
Covered by:
Web of Science
Fulltext / DOI:
doi:10.1101/2023.03.10.531286
WWW:
https://www.biorxiv.org/content/biorxiv/early/2023/03/12/2023.03.10.531286.full.pdf
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