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Titel:

Screening for potential targets to reduce stenosis in bioprosthetic heart valves.

Dokumenttyp:
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Foth, Rudi; Shomroni, Orr; Sigler, Matthias; Hörer, Jürgen; Cleuziou, Julie; Paul, Thomas; Eildermann, Katja
Abstract:
Progressive stenosis is one of the main factors that limit the lifetime of bioprosthetic valved conduits. To improve long-term performance we aimed to identify targets that inhibit pannus formation on conduit walls. From 11 explanted, obstructed, RNAlater presevered pulmonary valved conduits, we dissected the thickened conduit wall and the thin leaflet to determine gene expression-profiles using ultra deep sequencing. Differential gene expression between pannus and leaflet provided the dataset t...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2021
Band / Volume:
11
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41598-021-81340-2
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33510256
Print-ISSN:
2045-2322
TUM Einrichtung:
Klinik für Chirurgie angeborener Herzfehler und Kinderherzchirurgie (Prof. Hörer)
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