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Title:

An Approach to Controlling Inflammation and Coagulation in Pig-to-Baboon Cardiac Xenotransplantation.

Document type:
Journal Article
Author(s):
Bender, Martin; Reichart, Bruno; Figueiredo, Constanca; Burgmann, Jonathan M; Leuschen, Maria; Wall, Felicia; Radan, Julia; Neumann, Elisabeth; Mokelke, Maren; Buttgereit, Ines; Michel, Sebastian; Ellgass, Reinhard; Egerer, Stefanie; Lange, Andreas; Baehr, Andrea; Kessler, Barbara; Kemter, Elisabeth; Klymiuk, Nikolai; Denner, Joachim; Godehardt, Antonia W; Tönjes, Ralf R; Hagl, Christian; Gebauer, Michaela; Binder, Uli; Skerra, Arne; Ayares, David; Wolf, Eckhard; Schmoeckel, Michael; Brenner, Pa...     »
Abstract:
INTRODUCTION: Inflammatory responses and coagulation disorders are a relevant challenge for successful cardiac xenotransplantation on its way to the clinic. To cope with this, an effective and clinically practicable anti-inflammatory and anti-coagulatory regimen is needed. The inflammatory and coagulatory response can be reduced by genetic engineering of the organ-source pigs. Furthermore, there are several therapeutic strategies to prevent or reduce inflammatory responses and coagulation disord...     »
Journal title abbreviation:
Xenotransplantation
Year:
2024
Journal volume:
31
Journal issue:
4
Fulltext / DOI:
doi:10.1111/xen.12877
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/39077824
Print-ISSN:
0908-665X
TUM Institution:
585; Klinik und Poliklinik für Innere Medizin I, Kardiologie (Prof. Laugwitz); Professur für Kardiovaskuläre Translation in Großtiermodellen (Prof. Klymiuk)
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