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Title:

Vitronectin promotes immunothrombotic dysregulation in the venular microvasculature.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Uhl, Bernd; Haring, Florian; Slotta-Huspenina, Julia; Luft, Joshua; Schneewind, Vera; Hildinger, Jonas; Wu, Zhengquan; Steiger, Katja; Smiljanov, Bojan; Batcha, Aarif M N; Keppler, Oliver T; Hellmuth, Johannes C; Lahmer, Tobias; Stock, Konrad; Weiss, Bernhard G; Canis, Martin; Stark, Konstantin; Bromberger, Thomas; Moser, Markus; Schulz, Christian; Weichert, Wilko; Zuchtriegel, Gabriele; Reichel, Christoph A
Abstract:
Microvascular immunothrombotic dysregulation is a critical process in the pathogenesis of severe systemic inflammatory diseases. The mechanisms controlling immunothrombosis in inflamed microvessels, however, remain poorly understood. Here, we report that under systemic inflammatory conditions the matricellular glycoproteinvitronectin (VN) establishes an intravascular scaffold, supporting interactions of aggregating platelets with immune cells and the venular endothelium. Blockade of the VN recep...     »
Journal title abbreviation:
Front Immunol
Year:
2023
Journal volume:
14
Fulltext / DOI:
doi:10.3389/fimmu.2023.1078005
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36845099
Print-ISSN:
1664-3224
TUM Institution:
594; 606; 608; Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Klinik und Poliklinik für Innere Medizin II, Gastroenterologie (Prof. Schmid); Professur für Experimentelle Hämatologie (Prof. Schmidt-Supprian); Professur für Nephrologie (Prof. Heemann)
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