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Title:

Brief homogeneous TCR signals instruct common iNKT progenitors whose effector diversification is characterized by subsequent cytokine signaling.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Bortoluzzi, Sabrina; Dashtsoodol, Nyambayar; Engleitner, Thomas; Drees, Christoph; Helmrath, Sabine; Mir, Jonas; Toska, Albulena; Flossdorf, Michael; Öllinger, Rupert; Solovey, Maria; Colomé-Tatché, Maria; Kalfaoglu, Bahire; Ono, Masahiro; Buch, Thorsten; Ammon, Tim; Rad, Roland; Schmidt-Supprian, Marc
Abstract:
Innate-like T cell populations expressing conserved TCRs play critical roles in immunity through diverse developmentally acquired effector functions. Focusing on the prototypical lineage of invariant natural killer T (iNKT) cells, we sought to dissect the mechanisms and timing of fate decisions and functional effector differentiation. Utilizing induced expression of the semi-invariant NKT cell TCR on double positive thymocytes, an initially highly synchronous wave of iNKT cell development was tr...     »
Journal title abbreviation:
Immunity
Year:
2021
Journal volume:
54
Journal issue:
11
Pages contribution:
2497-2513.e9
Fulltext / DOI:
doi:10.1016/j.immuni.2021.09.003
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34562377
Print-ISSN:
1074-7613
TUM Institution:
Experimentelle Hämatologie (Prof. Schmidt-Supprian); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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