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Title:

Myotube growth is associated with cancer-like metabolic reprogramming and is limited by phosphoglycerate dehydrogenase

Document type:
Zeitschriftenaufsatz
Author(s):
Stadhouders, Lian E.M.; Smith, Jonathon A.B.; Gabriel, Brendan M.; Verbrugge, Sander A.J.; Hammersen, Tim D.; Kolijn, Detmar; Vogel, Ilse S.P.; Mohamed, Abdalla D.; de Wit, Gerard M.J.; Offringa, Carla; Hoogaars, Willem M.H.; Gehlert, Sebastian; Wackerhage, Henning; Jaspers, Richard T.
Abstract:
The Warburg effect links growth and glycolysis in cancer. A key purpose of the Warburg effect is to generate glycolytic intermediates for anabolic reactions, such as nucleotides → RNA/DNA and amino acids → protein synthesis. The aim of this study was to investigate whether a similar ‘glycolysis-for-anabolism’ metabolic reprogramming also occurs in hypertrophying skeletal muscle. To interrogate this, we first induced C2C12 myotube hypertrophy with IGF-1. We then added 14C glucose to the different...     »
Dewey Decimal Classification:
570 Biowissenschaften, Biologie
Journal title:
Experimental Cell Research
Year:
2023
Journal volume:
433
Year / month:
2023-12
Quarter:
4. Quartal
Month:
Dec
Journal issue:
2
Pages contribution:
113820
Covered by:
Web of Science
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1016/j.yexcr.2023.113820
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37879549
Publisher:
Elsevier BV
E-ISSN:
0014-4827
Impact Factor:
4,145
Scimago Quartil:
Q2
Notes:
SCImago Journal &  Country Rank
Status:
Erstveröffentlichung
Date of publication:
01.12.2023
Semester:
WS 23-24
TUM Institution:
Sportbiologie
Format:
Bild/Text
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