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Titel:

High RIPK3 expression is associated with a higher risk of early kidney transplant failure.

Dokumenttyp:
Journal Article
Autor(en):
Wahida, Adam; Schmaderer, Christoph; Büttner-Herold, Maike; Branca, Caterina; Donakonda, Sainitin; Haberfellner, Flora; Torrez, Carlos; Schmitz, Jessica; Schulze, Tobias; Seibt, Tobias; Öllinger, Rupert; Engleitner, Thomas; Haller, Bernhard; Steiger, Katja; Günthner, Roman; Lorenz, Georg; Yabal, Monica; Bachmann, Quirin; Braunisch, Matthias C; Moog, Philipp; Matevossian, Edouard; Aßfalg, Volker; Thorban, Stefan; Renders, Lutz; Späth, Martin R; Müller, Roman-Ulrich; Stippel, Dirk L; Weichert, Wil...     »
Abstract:
Renal ischemia-reperfusion injury (IRI) is associated with reduced allograft survival, and each additional hour of cold ischemia time increases the risk of graft failure and mortality following renal transplantation. Receptor-interacting protein kinase 3 (RIPK3) is a key effector of necroptosis, a regulated form of cell death. Here, we evaluate the first-in-human RIPK3 expression dataset following IRI in kidney transplantation. The primary analysis included 374 baseline biopsy samples obtained f...     »
Zeitschriftentitel:
iScience
Jahr:
2023
Band / Volume:
26
Heft / Issue:
10
Volltext / DOI:
doi:10.1016/j.isci.2023.107879
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37868627
TUM Einrichtung:
1062; 1298; Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Klinik und Poliklinik für Chirurgie (Prof. Friess); Lehrstuhl für Medizinische Informatik (Prof. Boeker); Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad); Professur für Nephrologie (Prof. Heemann); Roman Herzog Comprehensive Cancer Center
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