Benutzer: Gast  Login
Titel:

MDM2 Influences ACE2 Stability and SARS-CoV-2 Uptake

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Emslander, Quirin; Krey, Karsten; Hamad, Sabri; Maidl, Susanne; Oubraham, Lila; Hesse, Joshua; Henrici, Alexander; Austen, Katharina; Mergner, Julia; Grass, Vincent; Pichlmair, Andreas
Abstract:
Angiotensin-converting enzyme 2 (ACE2) is the central entry receptor for SARS-CoV-2. However, surprisingly little is known about the effects of host regulators on ACE2 localization, expression, and the associated influence on SARS-CoV-2 infection. Here we identify that ACE2 expression levels are regulated by the E3 ligase MDM2 and that MDM2 levels indirectly influence infection with SARS-CoV-2. Genetic depletion of MDM2 elevated ACE2 expression levels, which strongly promoted infection with all...     »
Stichworte:
BayBioMS@MRI; MDM2; SARS-CoV-2 uptake; angiotensin-converting enzyme 2 (ACE2); severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2); ubiquitination
Zeitschriftentitel:
Viruses
Jahr:
2023
Band / Volume:
15
Heft / Issue:
8
Seitenangaben Beitrag:
1763
Volltext / DOI:
doi:10.3390/v15081763
Verlag / Institution:
MDPI AG
E-ISSN:
1999-4915
Publikationsdatum:
18.08.2023
 BibTeX