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Title:

Long-term persistence and functionality of adoptively transferred antigen-specific T cells with genetically ablated PD-1 expression.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Dötsch, Sarah; Svec, Mortimer; Schober, Kilian; Hammel, Monika; Wanisch, Andreas; Gökmen, Füsun; Jarosch, Sebastian; Warmuth, Linda; Barton, Jack; Cicin-Sain, Luka; D'Ippolito, Elvira; Busch, Dirk H
Abstract:
Engagement of the inhibitory T cell receptor programmed cell death protein 1 (PD-1) associates with dysfunctional states of pathogen- or tumor-specific T cells. Accordingly, systemic antibody-mediated blockade of PD-1 has become a central target for immunotherapies but is also associated with severe toxicities due to loss of peripheral tolerance. Therefore, selective ablation of PD-1 expression on adoptively transferred T cells through direct genetic knockout (KO) is currently being explored as...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2023
Journal volume:
120
Journal issue:
10
Fulltext / DOI:
doi:10.1073/pnas.2200626120
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36853939
Print-ISSN:
0027-8424
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene (Prof. Busch)
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