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Title:

Significant Tumor Regression after Neoadjuvant Chemotherapy in Gastric Cancer, but Poor Survival of the Patient? Role of MHC Class I Alterations.

Document type:
Article; Journal Article
Author(s):
Hiltner, Theresa; Szörenyi, Noémi; Kohlruss, Meike; Hapfelmeier, Alexander; Herz, Anna-Lina; Slotta-Huspenina, Julia; Jesinghaus, Moritz; Novotny, Alexander; Lange, Sebastian; Ott, Katja; Weichert, Wilko; Keller, Gisela
Abstract:
We aimed to determine the clinical and prognostic relevance of allelic imbalance (AI) of the major histocompatibility complex (MHC) class I genes, encompassing the human leukocyte antigen (HLA) class I and beta-2 microglobulin (B2M) genes, in the context of neoadjuvant platinum/fluoropyrimidine chemotherapy (CTx). Biopsies before CTx were studied in 158 patients with adenocarcinoma of the stomach or gastroesophageal junction. The response was histopathologically evaluated. AI was detected by mul...     »
Journal title abbreviation:
Cancers (Basel)
Year:
2023
Journal volume:
15
Journal issue:
3
Fulltext / DOI:
doi:10.3390/cancers15030771
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36765729
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Klinik und Poliklinik für Chirurgie (Prof. Friess); Klinik und Poliklinik für Innere Medizin II, Gastroenterologie (Prof. Schmid); Lehrstuhl für Allgemeinmedizin (Prof. Schneider); Lehrstuhl für Medizinische Informatik (Prof. Boeker)
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