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Titel:

GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinoma.

Dokumenttyp:
Article; Journal Article
Autor(en):
de Andrés, Mónica P; Jackson, Richard J; Felipe, Irene; Zagorac, Sladjana; Pilarsky, Christian; Schlitter, Anna Melissa; Martinez de Villareal, Jaime; Jang, Gun Ho; Costello, Eithne; Gallinger, Steve; Ghaneh, Paula; Greenhalf, William; Knösel, Thomas; Palmer, Daniel H; Ruemmele, Petra; Weichert, Wilko; Buechler, Markus; Hackert, Thilo; Neoptolemos, John P; Notta, Faiyaz; Malats, Núria; Martinelli, Paola; Real, Francisco X
Abstract:
OBJECTIVE: GATA6 is a key regulator of the classical phenotype in pancreatic ductal adenocarcinoma (PDAC). Low GATA6 expression associates with poor patient outcome. GATA4 is the second most expressed GATA factor in the pancreas. We assessed whether, and how, GATA4 contributes to PDAC phenotype and analysed the association of expression with outcome and response to chemotherapy. DESIGN: We analysed PDAC transcriptomic data, stratifying cases according to GATA4 and GATA6 expression and identified...     »
Zeitschriftentitel:
Gut
Jahr:
2023
Band / Volume:
72
Heft / Issue:
3
Seitenangaben Beitrag:
535-548
Volltext / DOI:
doi:10.1136/gutjnl-2021-325803
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36109153
Print-ISSN:
0017-5749
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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