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Title:

Testing for deficient mismatch repair and microsatellite instability : A focused update.

Document type:
Journal Article; Review
Author(s):
Rüschoff, Josef; Schildhaus, Hans-Ulrich; Rüschoff, Jan Hendrik; Jöhrens, Korinna; Bocker Edmonston, Tina; Dietmaier, Wolfgang; Bläker, Hendrik; Baretton, Gustavo; Horst, David; Dietel, Manfred; Hartmann, Arndt; Klauschen, Frederick; Merkelbach-Bruse, Sabine; Stenzinger, Albrecht; Schöniger, Sandra; Tiemann, Markus; Weichert, Wilko; Büttner, Reinhard
Abstract:
Testing to detect mismatch repair deficiency (dMMR) and high-grade microsatellite instability (MSI-H) has become an integral part of the routine diagnostic workup for colorectal cancer (CRC). While MSI was initially considered to be a possible indicator of a hereditary disposition to cancer (Lynch syndrome, LS), today the prediction of the therapy response to immune checkpoint inhibitors (ICI) is in the foreground. Corresponding recommendations and testing algorithms are available for use in pri...     »
Journal title abbreviation:
Pathologie (Heidelb)
Year:
2023
Journal volume:
44
Journal issue:
Suppl 2
Pages contribution:
61-70
Fulltext / DOI:
doi:10.1007/s00292-023-01208-2
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37874379
Print-ISSN:
2731-7188
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.)
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