User: Guest  Login
Title:

Spatial Immunephenotypes of Distant Metastases but not Matched Primary Urothelial Carcinomas Predict Response to Immune Checkpoint Inhibition.

Document type:
Journal Article
Author(s):
Erlmeier, Franziska; Klümper, Niklas; Landgraf, Laura; Strissel, Pamela L; Strick, Reiner; Sikic, Danijel; Taubert, Helge; Wach, Sven; Geppert, Carol I; Bahlinger, Veronika; Breyer, Johannes; Ritter, Manuel; Bolenz, Christian; Roghmann, Florian; Erben, Philipp; Schwamborn, Kristina; Wirtz, Ralph M; Horn, Thomas; Wullich, Bernd; Hölzel, Michael; Hartmann, Arndt; Gschwend, Jürgen E; Weichert, Wilko; Eckstein, Markus
Abstract:
BACKGROUND: The value of programmed cell death ligand-1 (PD-L1) to predict durable responses to immune checkpoint inhibitors (ICIs) in metastatic urothelial carcinoma (mUC) is inconsistent. We hypothesize that the use of archived primary tumor material (PRIM) for PD-L1 testing in clinical trials not properly reflecting the metastatic disease status (MET) contributes to this clinical issue. OBJECTIVE: To analyze the predictive and prognostic value of PD-L1, spatial immunephenotypes, and major his...     »
Journal title abbreviation:
Eur Urol
Year:
2023
Journal volume:
83
Journal issue:
2
Pages contribution:
133-142
Fulltext / DOI:
doi:10.1016/j.eururo.2022.10.020
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36372626
Print-ISSN:
0302-2838
TUM Institution:
551; Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Urologie
 BibTeX