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Title:

Histological evaluation of PAXgene tissue fixation in Barrett's esophagus and esophageal adenocarcinoma diagnostics.

Document type:
Journal Article
Author(s):
Barroux, Melissa; Horstmann, Julia; Fricke, Lisa; Schömig, Linus; Werner, Martin; Kraynova, Ekaterina; Kamarádová, Katerina; Fléjou, Jean-François; Maerkel, Bruno; Kumarasinghe, M Priyanthi; Vieth, Michael; Westerhoff, Maria; Patil, Deepa T; Steiger, Katja; Becker, Karl-Friedrich; Weichert, Wilko; Schmid, Roland M; Quante, Michael; Slotta-Huspenina, Julia
Abstract:
The dysplasia grading of Barrett's esophagus (BE), based on the histomorphological assessment of formalin-fixed, paraffin-embedded (FFPE) tissue, suffers from high interobserver variability leading to an unsatisfactory prediction of cancer risk. Thus, pre-analytic preservation of biological molecules, which could improve risk prediction in BE enabling molecular and genetic analysis, is needed. We aimed to evaluate such a molecular pre-analytic fixation tool, PAXgene-fixed paraffin-embedded (PFPE...     »
Journal title abbreviation:
Virchows Arch
Year:
2023
Journal volume:
482
Journal issue:
5
Pages contribution:
887-898
Fulltext / DOI:
doi:10.1007/s00428-022-03471-9
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36527466
Print-ISSN:
0945-6317
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Klinik und Poliklinik für Innere Medizin II, Gastroenterologie (Prof. Schmid)
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