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Titel:

Low microsatellite instability: A distinct instability type in gastric cancer?

Dokumenttyp:
Journal Article
Autor(en):
Kohlruss, Meike; Chakraborty, Shounak; Hapfelmeier, Alexander; Jesinghaus, Moritz; Slotta-Huspenina, Julia; Novotny, Alexander; Sisic, Leila; Gaida, Matthias M; Ott, Katja; Weichert, Wilko; Pfarr, Nicole; Keller, Gisela
Abstract:
PURPOSE: We recently showed that low microsatellite instability (MSI-L) is associated with a good response to platinum/5-fluorouracil (5-FU) neoadjuvant chemotherapy (CTx) in gastric cancer. The purpose of this study was to characterize the instability pattern and to investigate an association of MSI-L tumors with mutations in genes of DNA repair pathways and with total tumor mutation burden (TMB). METHODS: MSI patterns were compared between 67 MSI high (-H) and 35 MSI-L tumors. Whole-exome sequ...     »
Zeitschriftentitel:
J Cancer Res Clin Oncol
Jahr:
2023
Band / Volume:
149
Heft / Issue:
20
Seitenangaben Beitrag:
17727-17737
Volltext / DOI:
doi:10.1007/s00432-023-05430-6
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37819581
Print-ISSN:
0171-5216
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Klinik und Poliklinik für Chirurgie (Prof. Friess); Lehrstuhl für Medizinische Informatik (Prof. Boeker)
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