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Title:

Enhanced Sensitivity to ALDH1A3-Dependent Ferroptosis in TMZ-Resistant Glioblastoma Cells.

Document type:
Article; Journal Article
Author(s):
Wu, Yang; Franzmeier, Sophie; Liesche-Starnecker, Friederike; Schlegel, Jürgen
Abstract:
Temozolomide (TMZ) is standard treatment for glioblastoma (GBM); nonetheless, resistance and tumor recurrence are still major problems. In addition to its association with recurrent GBM and TMZ resistance, ALDH1A3 has a role in autophagy-dependent ferroptosis activation. In this study, we treated TMZ-resistant LN229 human GBM cells with the ferroptosis inducer RSL3. Remarkably, TMZ-resistant LN229 clones were also resistant to ferroptosis induction, although lipid peroxidation was induced by RS...     »
Journal title abbreviation:
Cells
Year:
2023
Journal volume:
12
Journal issue:
21
Fulltext / DOI:
doi:10.3390/cells12212522
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37947601
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.)
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