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Titel:

A burning question from the first international BPAN symposium: is restoration of autophagy a promising therapeutic strategy for BPAN?

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Mollereau, Bertrand; Hayflick, Susan J; Escalante, Ricardo; Mauthe, Mario; Papandreou, Apostolos; Iuso, Arcangela; Celle, Marion; Aniorte, Sahra; Issa, Abdul Raouf; Lasserre, Jean Paul; Lesca, Gaetan; Thobois, Stéphane; Burger, Pauline; Walter, Ludivine
Abstract:
Beta-propeller protein-associated neurodegeneration (BPAN) is a rare neurodegenerative disease associated with severe cognitive and motor deficits. BPAN pathophysiology and phenotypic spectrum are still emerging due to the fact that mutations in the WDR45 (WD repeat domain 45) gene, a regulator of macroautophagy/autophagy, were only identified a decade ago. In the first international symposium dedicated to BPAN, which was held in Lyon, France, a panel of international speakers, including several...     »
Zeitschriftentitel:
Autophagy
Jahr:
2023
Band / Volume:
19
Heft / Issue:
12
Seitenangaben Beitrag:
3234-3239
Volltext / DOI:
doi:10.1080/15548627.2023.2247314
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37565733
Print-ISSN:
1554-8627
TUM Einrichtung:
Institut für Humangenetik (Prof. Winkelmann)
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