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- Original title:
- Mechanistic Studies on Polyketide Biosynthesis in Pathogenic Fungi and Bacteria
- Translated title:
- Mechanistische Untersuchungen zur Biosynthese von Polyketiden in pathogenen Pilzen und Bakterien
- Author:
- Schmalhofer, Maximilian
- Year:
- 2023
- Document type:
- Dissertation
- Faculty/School:
- TUM School of Natural Sciences
- Advisor:
- Groll, Michael (Prof. Dr.)
- Referee:
- Groll, Michael (Prof. Dr.); Brück, Thomas (Prof. Dr.); Bode, Helge B. (Prof. Dr.)
- Language:
- en
- Subject group:
- CHE Chemie
- TUM classification:
- CHE 800
- Abstract:
- Aryl polyene lipids (APELs), 1,8-dihydroxynaphthalene (DHN)-melanin, and anthraquinone (AQ) are polyketides produced by pathogenic bacteria or fungi. APELs are built by aryl polyene (APE) type II polyketide synthases (PKSs) in most Gram-negative bacteria, DHN-melanin is a virulence factor in Aspergillus fumigatus, and AQ is present in Photorhabdus laumondii. This work provides mechanistic insights into their biosynthesis on a structural level and builds the foundation for further studies and the... »
- Translated abstract:
- Aryl Polyen Lipide (APELs), 1,8-Dihydroxynapthalin (DHN)-Melanin und Anthrachinon (AQ) sind Polyketide, die von pathogenen Bakterien oder Pilzen hergestellt werden. APELs werden von Aryl Polyen (APE) Typ II Polyketidsynthasen (PKSs) in den meisten gramnegativen Bakterien gebildet, DHN-Melanin ist ein Virulenzfaktor in Aspergillus fumigatus, und AQ ist in Photorhabdus laumondii vorhanden. Diese Arbeit liefert mechanistische Einblicke in ihre Biosynthese auf struktureller Ebene und bildet die Grun... »
- WWW:
- https://mediatum.ub.tum.de/?id=1711116
- Date of submission:
- 31.05.2023
- Oral examination:
- 28.07.2023
- File size:
- 52091606 bytes
- Pages:
- 105
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20230728-1711116-1-6
- Last change:
- 28.07.2024
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