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Original title:
Investigation of functional and structural divergence of the Hsp16 chaperone family in Caenorhabditis elegans
Translated title:
Untersuchung der funktionellen und strukturellen Divergenz der Hsp16-Chaperonfamilie in Caenorhabditis elegans
Author:
Bushman, Yevheniia
Year:
2023
Document type:
Dissertation
Faculty/School:
TUM School of Natural Sciences
Advisor:
Buchner, Johannes (Prof. Dr.)
Referee:
Buchner, Johannes (Prof. Dr.); Reif, Bernd (Prof. Dr.)
Language:
en
Subject group:
CIT Chemie-Ingenieurwesen, Technische Chemie, Biotechnologie
Keywords:
Hsp, stress response, C. elegans, duplication
TUM classification:
CHE 800; CIT 900
Abstract:
Small heat shock proteins (sHsp) keep unfolding substrates from unspecific aggregation by forming complexes with them. Although we know that sHsps protect unfolding substrate proteins, key questions regarding their functional and structural diversity are yet to be answered. This study defines the similarities and differences of the members of the Hsp16 family of C. elegans by investigating their structure and functions in a comparative manner in regards of their high homology.
Translated abstract:
Kleine Hitzeschockproteine (sHsps) schützen entfaltete Substrate vor unspezifischer Aggregation, indem sie Komplexe mit ihnen bilden. Obwohl wir wissen, dass sHsps entfaltete Substratproteine schützen, bleiben wichtige Fragen über ihre funktionelle und strukturelle Vielfalt unbeantwortet. In dieser Studie definiere ich die Ähnlichkeiten und Unterschiede zwischen den Hsp16s von C. elegans, indem ich ihre Struktur und Funktionen im Lichte ihrer hohen Homologie vergleichend untersuche.
WWW:
https://mediatum.ub.tum.de/?id=1686079
Date of submission:
26.09.2022
Oral examination:
18.01.2023
File size:
11292924 bytes
Pages:
184
Urn (citeable URL):
https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20230118-1686079-1-1
Last change:
18.01.2025
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