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Titel:

Generation and identification of a conditional knockout allele for the PSMD11 gene in mice.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Zhao, Linlin; Zhao, Jinming; Zhang, Yingying; Wang, Lele; Zuo, Longyan; Niu, Airu; Zhang, Wei; Xue, Xia; Zhao, Suhong; Sun, Chao; Li, Kailin; Wang, Jue; Bian, Zhimin; Zhao, Xiaogang; Saur, Dieter; Seidler, Barbara; Wang, Chuanxin; Qi, Tonggang
Abstract:
BACKGROUND: Our previous study have shown that the PSMD11 protein was an important survival factor for cancer cells except for its key role in regulation of assembly and activity of the 26S proteasome. To further investigate the role of PSMD11 in carcinogenesis, we constructed a conditional exon 5 floxed allele of PSMD11 (PSMD11flx) in mice. RESULTS: It was found that homozygous PSMD11 flx/flx mice showed normal and exhibited a normal life span and fertility, and showed roughly equivalent expres...     »
Zeitschriftentitel:
BMC Dev Biol
Jahr:
2021
Band / Volume:
21
Heft / Issue:
1
Volltext / DOI:
doi:10.1186/s12861-020-00233-1
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33517884
Print-ISSN:
1471-213X
TUM Einrichtung:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur)
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