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Titel:

A GATA6-centred gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Kloesch, Bernhard; Ionasz, Vivien; Paliwal, Sumit; Hruschka, Natascha; Martinez de Villarreal, Jaime; Öllinger, Rupert; Mueller, Sebastian; Dienes, Hans Peter; Schindl, Martin; Gruber, Elisabeth S; Stift, Judith; Herndler-Brandstetter, Dietmar; Lomberk, Gwen A; Seidler, Barbara; Saur, Dieter; Rad, Roland; Urrutia, Raul A; Real, Francisco X; Martinelli, Paola
Abstract:
OBJECTIVE: Molecular taxonomy of tumours is the foundation of personalised medicine and is becoming of paramount importance for therapeutic purposes. Four transcriptomics-based classification systems of pancreatic ductal adenocarcinoma (PDAC) exist, which consistently identified a subtype of highly aggressive PDACs with basal-like features, including ΔNp63 expression and loss of the epithelial master regulator GATA6. We investigated the precise molecular events driving PDAC progression and the e...     »
Zeitschriftentitel:
Gut
Jahr:
2022
Band / Volume:
71
Heft / Issue:
4
Seitenangaben Beitrag:
766-777
Volltext / DOI:
doi:10.1136/gutjnl-2020-321397
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33846140
Print-ISSN:
0017-5749
TUM Einrichtung:
Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur); Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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