Efficacy of ultrasound assisted catheter-directed thrombolysis compared to catheter-directed thrombolysis in vitro.

Nadjiri, Jonathan; Kierse, Anna; Sendlbeck, Melanie; Janssen, Agnes; Geith, Tobias; Waggershauser, Tobias; Paprottka, Philipp M

doi:10.1177/02841851211061440

2023

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Title:: Efficacy of ultrasound assisted catheter-directed thrombolysis compared to catheter-directed thrombolysis in vitro.
Document type:: Journal Article
Author(s):: Nadjiri, Jonathan; Kierse, Anna; Sendlbeck, Melanie; Janssen, Agnes; Geith, Tobias; Waggershauser, Tobias; Paprottka, Philipp M
Abstract:: BACKGROUND: Catheter-directed thrombolysis (CDT) is an effective and safe endovascular method used in critical limb ischemia and many other thromboembolic events. Ultrasound-assisted catheter-directed thrombolysis (US-CDT) is an emerging technique considered to accelerate thrombolysis and therefore is supposed to improve outcome. PURPOSE: To evaluate the efficacy of US-CDT in comparison to standard CDT in vitro. MATERIAL AND METHODS: A total of 69 sets of human venous blood were evaluated, each comprising a tube just treated with CDT, a tube treated with US-CDT, and a control tube. All tubes were kept under physiological conditions. Except for the controls, in all tubes 5 mg of tissue-type plasminogen activator was administered over the predetermined treatment interval. Thrombus mass was weighted at the end of the lysis intervals at 6 h or 24 h, respectively. RESULTS: CDT led to a mean thrombus reduction of 32% and ultrasound-assisted lysis led to a mean thrombus reduction of 41% (P < 0.001 for both). Thrombus reduction was significantly higher after US-CDT compared to CDT (P = 0.001). The better efficacy of US-CDT was mostly already apparent at early phases during thrombolysis and did further mildly increase over time (r = 0.24; P = 0.047). CONCLUSION: In vitro US-CDT is significantly superior to standard CDT; this effect is apparent at an early timepoint of lysis and slightly further increases over time.
Journal title abbreviation:: Acta Radiol
Year:: 2023
Journal volume:: 64
Journal issue:: 1
Pages contribution:: 119-124
Fulltext / DOI:: doi:10.1177/02841851211061440
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/34866428
Print-ISSN:: 0284-1851
TUM Institution:: Professur für Interventionelle Radiologie (Prof. Paprottka)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für Diagnostische und Interventionelle Radiologie (Prof. Makowski)Professur für Interventionelle Radiologie (Prof. Paprottka)2023

mediaTUM Gesamtbestand Hochschulbibliographie 2023 Schools und Fakultäten Medizin Institut für Radiologie