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Titel:

Lung Epithelial CYP1 Activity Regulates Aryl Hydrocarbon Receptor Dependent Allergic Airway Inflammation.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Alessandrini, Francesca; de Jong, Renske; Wimmer, Maria; Maier, Ann-Marie; Fernandez, Isis; Hils, Miriam; Buters, Jeroen T; Biedermann, Tilo; Zissler, Ulrich M; Hoffmann, Christian; Esser-von-Bieren, Julia; Schmidt-Weber, Carsten B; Ohnmacht, Caspar
Abstract:
The lung epithelial barrier serves as a guardian towards environmental insults and responds to allergen encounter with a cascade of immune reactions that can possibly lead to inflammation. Whether the environmental sensor aryl hydrocarbon receptor (AhR) together with its downstream targets cytochrome P450 (CYP1) family members contribute to the regulation of allergic airway inflammation remains unexplored. By employing knockout mice for AhR and for single CYP1 family members, we found that AhR-/...     »
Zeitschriftentitel:
Front Immunol
Jahr:
2022
Band / Volume:
13
Volltext / DOI:
doi:10.3389/fimmu.2022.901194
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35734174
Print-ISSN:
1664-3224
TUM Einrichtung:
604; Klinik und Poliklinik für Dermatologie und Allergologie; Lehrstuhl für Molekulare Allergologie und Umweltforschung (Prof. Schmidt-Weber)
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