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Titel:

JAK-STAT1 Signaling Pathway Is an Early Response to Helicobacter pylori Infection and Contributes to Immune Escape and Gastric Carcinogenesis.

Dokumenttyp:
Journal Article
Autor(en):
Li, Xue; Pan, Kaifeng; Vieth, Michael; Gerhard, Markus; Li, Wenqing; Mejías-Luque, Raquel
Abstract:
Helicobacter pylori infection induces a number of pro-inflammatory signaling pathways contributing to gastric inflammation and carcinogenesis and has been identified as a major risk factor for the development of gastric cancer (GC). Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling mediates immune regulatory processes, including tumor-driven immune escape. Programmed death ligand 1 (PD-L1) expressed on gastric epithelium can suppress the immune system by shutting...     »
Zeitschriftentitel:
Int J Mol Sci
Jahr:
2022
Band / Volume:
23
Heft / Issue:
8
Volltext / DOI:
doi:10.3390/ijms23084147
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35456965
Print-ISSN:
1422-0067
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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