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Title:

Next generation automated traceless cell chromatography platform for GMP-compliant cell isolation and activation.

Document type:
Journal Article
Author(s):
Radisch, Sabine; Poltorak, Mateusz P; Wagner, Michaela; Cletiu, Vlad; Radisch, Christian; Treise, Irina; Pann, Steffi; Weigt, Alexis; Artner, Sophie; Dreher, Stefan; Fechner, Fabian; Borjan, Bojana; Fraessle, Simon P; Effenberger, Manuel; Benke, Eileen; Navratil, Gottfried; Hentschel, Norbert; Busch, Dirk H; Schmidt, Thomas; Stemberger, Christian; Germeroth, Lothar
Abstract:
Large-scale target cell isolation from patient blood preparations is one of the critical operations during drug product manufacturing for personalized cell therapy in immuno-oncology. Use of high-affinity murine antibody coated magnetic nanoparticles that remain on isolated cells is the current standard applied for this purpose. Here, we present the transformation of previously described technology - non-magnetic immunoaffinity column chromatography-based cell selection with reversible reagents...     »
Journal title abbreviation:
Sci Rep
Year:
2022
Journal volume:
12
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41598-022-10320-x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35449227
Print-ISSN:
2045-2322
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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