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Titel:

FoxP3 expression by retinal pigment epithelial cells: transcription factor with potential relevance for the pathology of age-related macular degeneration.

Dokumenttyp:
Journal Article
Autor(en):
Alfaar, Ahmad Samir; Stürzbecher, Lucas; Diedrichs-Möhring, Maria; Lam, Marion; Roubeix, Christophe; Ritter, Julia; Schumann, Kathrin; Annamalai, Balasubramaniam; Pompös, Inga-Marie; Rohrer, Bärbel; Sennlaub, Florian; Reichhart, Nadine; Wildner, Gerhild; Strauß, Olaf
Abstract:
BACKGROUND: Forkhead-Box-Protein P3 (FoxP3) is a transcription factor and marker of regulatory T cells, converting naive T cells into Tregs that can downregulate the effector function of other T cells. We previously detected the expression of FoxP3 in retinal pigment epithelial (RPE) cells, forming the outer blood-retina barrier of the immune privileged eye. METHODS: We investigated the expression, subcellular localization, and phosphorylation of FoxP3 in RPE cells in vivo and in vitro after tre...     »
Zeitschriftentitel:
J Neuroinflammation
Jahr:
2022
Band / Volume:
19
Heft / Issue:
1
Volltext / DOI:
doi:10.1186/s12974-022-02620-w
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36273134
Print-ISSN:
1742-2094
TUM Einrichtung:
588; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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