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Titel:

CRISPR/Cas-based Human T cell Engineering: Basic Research and Clinical Application.

Dokumenttyp:
Journal Article; Review; Research Support, Non-U.S. Gov't
Autor(en):
Bernard, Bettina E; Landmann, Emmanuelle; Jeker, Lukas T; Schumann, Kathrin
Abstract:
Engineering human T cells for the treatment of cancer, viral infections and autoimmunity has been a long-standing dream of many immunologists and hematologists. Although primary human T cells have been genetically engineered for decades, this process was challenging, time consuming and mostly limited to transgene insertions mediated by viral transduction. The absence of widely accessible tools to efficiently and precisely engineer T cells genetically in a targeted manner limited their applicabil...     »
Zeitschriftentitel:
Immunol Lett
Jahr:
2022
Band / Volume:
245
Seitenangaben Beitrag:
18-28
Volltext / DOI:
doi:10.1016/j.imlet.2022.03.005
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35358611
Print-ISSN:
0165-2478
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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