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Title:

Whole Exome Sequencing of Biliary Tubulopapillary Neoplasms Reveals Common Mutations in Chromatin Remodeling Genes

Document type:
Article
Author(s):
Gross, Claudia; Engleitner, Thomas; Lange, Sebastian; Weber, Julia; Jesinghaus, Moritz; Konukiewitz, Bjoern; Muckenhuber, Alexander; Steiger, Katja; Pfarr, Nicole; Goeppert, Benjamin; Keller, Gisela; Weichert, Wilko; Adsay, Nazmi Volkan; Kloeppel, Gunter; Rad, Roland; Esposito, Irene; Schlitter, Anna Melissa
Abstract:
Simple Summary Intraductal tubulopapillary neoplasms (ITPN) have recently been described as rare precursor lesions of pancreatic ductal adenocarcinoma and cholangiocarcinoma. Despite a high number of associated invasive adenocarcinomas at the time of diagnosis, patients with ITPN tend to have a much better clinical outcome than those with classical pancreato-biliary adenocarcinoma. Furthermore, rare molecular studies of ITPN show an unexpected lack of hotspot mutations in common driver genes...     »
Journal title abbreviation:
Cancers (Basel)
Year:
2021
Journal volume:
13
Journal issue:
11
Fulltext / DOI:
doi:10.3390/cancers13112742
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34205964
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur); Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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