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Titel:

Immune deficiency is a risk factor for severe COVID-19 in people living with HIV.

Dokumenttyp:
Article; Journal Article; Multicenter Study
Autor(en):
Hoffmann, Christian; Casado, José L; Härter, Georg; Vizcarra, Pilar; Moreno, Ana; Cattaneo, Dario; Meraviglia, Paola; Spinner, Christoph D; Schabaz, Farhad; Grunwald, Stephan; Gervasoni, Cristina
Abstract:
OBJECTIVES: A prior T cell depletion induced by HIV infection may carry deleterious consequences in the current COVID-19 pandemic. Clinical data on patients co-infected with HIV and SARS-CoV-2 are still scarce. METHODS: This multicentre cohort study evaluated risk factors for morbidity and mortality of COVID-19 in people living with HIV (PLWH), infected with SARS-CoV-2 in three countries in different clinical settings. COVID-19 was clinically classified as to be mild-to-moderate or severe. RESULTS: Of 175 patients, 49 (28%) had severe COVID-19 and 7 (4%) patients died. Almost all patients were on antiretroviral therapy (ART) and in 94%, HIV RNA was below 50 copies/mL prior to COVID-19 diagnosis. In the univariate analysis, an age 50 years or older, a CD4+ T cell nadir of < 200/µl, current CD4+ T cells < 350/µl and the presence of at least one comorbidity were significantly associated with severity of COVID-19. No significant association was found for gender, ethnicity, obesity, a detectable HIV RNA, a prior AIDS-defining illness, or tenofovir (which was mainly given as alafenamide) or protease inhibitor use in the current ART. In a multivariate analysis, the only factor associated with risk for severe COVID-19 was a current CD4+ T cell count of < 350/µl (adjusted odds ratio 2.85, 95% confidence interval 1.26-6.44, p=0.01). The only factor associated with mortality was a low CD4 T cell nadir. CONCLUSIONS: In PLWH, immune deficiency is a possible risk factor for severe COVID-19, even in the setting of virological suppression. There is no evidence for a protective effect of PIs or tenofovir alafenamide.
Zeitschriftentitel:
HIV Med
Jahr:
2021
Band / Volume:
22
Heft / Issue:
5
Seitenangaben Beitrag:
372-378
Volltext / DOI:
doi:10.1111/hiv.13037
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33368966
Print-ISSN:
1464-2662
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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