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Titel:

Aquaporin-4 prevents exaggerated astrocytosis and structural damage in retinal inflammation.

Dokumenttyp:
Journal Article
Autor(en):
Maisam Afzali, Ali; Stüve, Lasse; Pfaller, Monika; Aly, Lilian; Steiger, Katja; Knier, Benjamin; Korn, Thomas
Abstract:
Aquaporin-4 (AQP4) is the molecular target of the immune response in neuromyelitis optica (NMO) that leads to severe structural damage in the central nervous system (CNS) and in the retina. Conversely, AQP4 might be upregulated in astrocytes as a compensatory event in multiple sclerosis. Thus, the functional relevance of AQP4 in neuroinflammation needs to be defined. Here, we tested the role of AQP4 in the retina in MOG(35-55)-induced experimental autoimmune encephalomyelitis (EAE) using optical...     »
Zeitschriftentitel:
J Mol Med
Jahr:
2022
Band / Volume:
100
Heft / Issue:
6
Seitenangaben Beitrag:
933-946
Volltext / DOI:
doi:10.1007/s00109-022-02202-6
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35536323
Print-ISSN:
0946-2716
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Neurologie; Molekulare Immunologie (Prof. Knolle)
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