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Titel:

Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Zhou, Dingxi; Borsa, Mariana; Puleston, Daniel J; Zellner, Susanne; Capera, Jesusa; Sanderson, Sharon; Schifferer, Martina; Hester, Svenja S; Ge, Xin; Fischer, Roman; Jostins, Luke; Behrends, Christian; Alsaleh, Ghada; Simon, Anna Katharina
Abstract:
CD4+ T cells are pivotal cells playing roles in the orchestration of humoral and cytotoxic immune responses. It is known that CD4+ T cell proliferation relies on autophagy, but identification of the autophagosomal cargo involved is missing. Here we create a transgenic mouse model, to enable direct mapping of the proteinaceous content of autophagosomes in primary cells by LC3 proximity labelling. Interleukin-7 receptor-α, a cytokine receptor mostly found in naïve and memory T cells, is reproducib...     »
Zeitschriftentitel:
Nat Commun
Jahr:
2022
Band / Volume:
13
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41467-022-32718-x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36055998
Print-ISSN:
2041-1723
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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