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Title:

Age-dependent increase of cytoskeletal components in sensory axons in human skin.

Document type:
Article; Journal Article
Author(s):
Metzner, Klara; Darawsha, Omar; Wang, Mengzhe; Gaur, Nayana; Cheng, Yiming; Rödiger, Annekathrin; Frahm, Christiane; Witte, Otto W; Perocchi, Fabiana; Axer, Hubertus; Grosskreutz, Julian; Brill, Monika S
Abstract:
Aging is a complex process characterized by several molecular and cellular imbalances. The composition and stability of the neuronal cytoskeleton is essential for the maintenance of homeostasis, especially in long neurites. Using human skin biopsies containing sensory axons from a cohort of healthy individuals, we investigate alterations in cytoskeletal content and sensory axon caliber during aging via quantitative immunostainings. Cytoskeletal components show an increase with aging in both sexe...     »
Journal title abbreviation:
Front Cell Dev Biol
Year:
2022
Journal volume:
10
Fulltext / DOI:
doi:10.3389/fcell.2022.965382
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36393849
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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