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Title:

Ketogenic diet uncovers differential metabolic plasticity of brain cells.

Document type:
Article; Journal Article
Author(s):
Düking, Tim; Spieth, Lena; Berghoff, Stefan A; Piepkorn, Lars; Schmidke, Annika M; Mitkovski, Miso; Kannaiyan, Nirmal; Hosang, Leon; Scholz, Patricia; Shaib, Ali H; Schneider, Lennart V; Hesse, Dörte; Ruhwedel, Torben; Sun, Ting; Linhoff, Lisa; Trevisiol, Andrea; Köhler, Susanne; Pastor, Adrian Marti; Misgeld, Thomas; Sereda, Michael; Hassouna, Imam; Rossner, Moritz J; Odoardi, Francesca; Ischebeck, Till; de Hoz, Livia; Hirrlinger, Johannes; Jahn, Olaf; Saher, Gesine
Abstract:
To maintain homeostasis, the body, including the brain, reprograms its metabolism in response to altered nutrition or disease. However, the consequences of these challenges for the energy metabolism of the different brain cell types remain unknown. Here, we generated a proteome atlas of the major central nervous system (CNS) cell types from young and adult mice, after feeding the therapeutically relevant low-carbohydrate, high-fat ketogenic diet (KD) and during neuroinflammation. Under steady-st...     »
Journal title abbreviation:
Sci Adv
Year:
2022
Journal volume:
8
Journal issue:
37
Fulltext / DOI:
doi:10.1126/sciadv.abo7639
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36112685
Print-ISSN:
2375-2548
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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