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Title:

Multimeric ACE2-IgM fusions as broadly active antivirals that potently neutralize SARS-CoV-2 variants.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Svilenov, Hristo L; Bester, Romina; Sacherl, Julia; Absmeier, Ramona; Peters, Carsten; Protzer, Ulrike; Brockmeyer, Carsten; Buchner, Johannes
Abstract:
Coronavirus infections are a world-wide threat to human health. A promising strategy to develop a broadly active antiviral is the use of fusion proteins consisting of an antibody IgG Fc region and a human ACE2 domain to which the viral spike proteins bind. Here we create antiviral fusion proteins based on IgM scaffolds. The hexameric ACE2-IgM-Fc fusions can be efficiently produced in mammalian cells and they neutralize the infectious virus with picomolar affinity thus surpassing monomeric ACE2-I...     »
Journal title abbreviation:
Commun Biol
Year:
2022
Journal volume:
5
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s42003-022-04193-z
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36371561
TUM Institution:
Institut für Virologie (Prof. Protzer)
 BibTeX