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Title:

Influenza A Virus Infection Reactivates Human Endogenous Retroviruses Associated with Modulation of Antiviral Immunity.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Liu, Hengyuan; Bergant, Valter; Frishman, Goar; Ruepp, Andreas; Pichlmair, Andreas; Vincendeau, Michelle; Frishman, Dmitrij
Abstract:
Human endogenous retrovirus (HERVs), normally silenced by methylation or mutations, can be reactivated by multiple environmental factors, including infections with exogenous viruses. In this work, we investigated the transcriptional activity of HERVs in human A549 cells infected by two wild-type (PR8M, SC35M) and one mutated (SC35MΔNS1) strains of Influenza A virus (IAVs). We found that the majority of differentially expressed HERVs (DEHERVS) and genes (DEGs) were up-regulated in the infected ce...     »
Journal title abbreviation:
Viruses
Year:
2022
Journal volume:
14
Journal issue:
7
Fulltext / DOI:
doi:10.3390/v14071591
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35891571
Print-ISSN:
1999-4915
TUM Institution:
Institut für Virologie (Prof. Protzer)
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