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Title:

Optimization of an Efficient Cell Culture Hepatitis B Infection System for Assessment of Hepatitis B Virus Neutralizing Monoclonal Antibodies.

Document type:
Journal Article
Author(s):
Sarvnaz, Hamzeh; Asadi-Asadabad, Sahar; Amiri, Mohammad Mehdi; Ghaedi, Mojgan; Protzer, Ulrike; Jeddi-Tehrani, Mahmood; Golsaz-Shirazi, Forough; Shokri, Fazel
Abstract:
BACKGROUND: Human polyclonal plasma-derived hepatitis B immunoglobulin (HBIG) is currently used for immunoprophylaxis of HBV infection. The development of virus-neutralizing monoclonal antibodies (MAbs) requires the use of optimized cell culture systems supporting HBV infection. OBJECTIVE: This study aims to optimize the hepatitis B virus infectivity of NTCP-reconstituted HepG2 (HepG2-NTCP) cells to establish an efficient system to evaluate the HBV-neutralizing effect of anti-HBs MAbs. METHODS:...     »
Journal title abbreviation:
Iran J Immunol
Year:
2022
Journal volume:
19
Journal issue:
3
Pages contribution:
278-298
Fulltext / DOI:
doi:10.22034/iji.2022.94266.2298
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36190382
Print-ISSN:
1735-1383
TUM Institution:
Institut für Virologie (Prof. Protzer)
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