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Titel:

Hepatitis B virus X protein counteracts high mobility group box 1 protein-mediated epigenetic silencing of covalently closed circular DNA.

Dokumenttyp:
Journal Article
Autor(en):
Kim, Elena S; Zhou, Jun; Zhang, Hu; Marchetti, Alexander; van de Klundert, Maarten; Cai, Dawei; Yu, Xiaoyang; Mitra, Bidisha; Liu, Yuanjie; Wang, Mu; Protzer, Ulrike; Guo, Haitao
Abstract:
Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA), serving as the viral persistence form and transcription template of HBV infection, hijacks host histone and non-histone proteins to form a minichromosome and utilizes posttranslational modifications (PTMs) "histone code" for its transcriptional regulation. HBV X protein (HBx) is known as a cccDNA transcription activator. In this study we established a dual system of the inducible reporter cell lines modelling infection with wildtyp...     »
Zeitschriftentitel:
PLoS Pathog
Jahr:
2022
Band / Volume:
18
Heft / Issue:
6
Volltext / DOI:
doi:10.1371/journal.ppat.1010576
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35679251
Print-ISSN:
1553-7366
TUM Einrichtung:
Institut für Virologie (Prof. Protzer)
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