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Title:

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Stukalov, Alexey; Girault, Virginie; Grass, Vincent; Karayel, Ozge; Bergant, Valter; Urban, Christian; Haas, Darya A; Huang, Yiqi; Oubraham, Lila; Wang, Anqi; Hamad, M Sabri; Piras, Antonio; Hansen, Fynn M; Tanzer, Maria C; Paron, Igor; Zinzula, Luca; Engleitner, Thomas; Reinecke, Maria; Lavacca, Teresa M; Ehmann, Rosina; Wölfel, Roman; Jores, Jörg; Kuster, Bernhard; Protzer, Ulrike; Rad, Roland; Ziebuhr, John; Thiel, Volker; Scaturro, Pietro; Mann, Matthias; Pichlmair, Andreas
Abstract:
The emergence and global spread of SARS-CoV-2 has resulted in the urgent need for an in-depth understanding of molecular functions of viral proteins and their interactions with the host proteome. Several individual omics studies have extended our knowledge of COVID-19 pathophysiology1-10. Integration of such datasets to obtain a holistic view of virus-host interactions and to define the pathogenic properties of SARS-CoV-2 is limited by the heterogeneity of the experimental systems. Here we repor...     »
Journal title abbreviation:
Nature
Year:
2021
Journal volume:
594
Journal issue:
7862
Pages contribution:
246-252
Fulltext / DOI:
doi:10.1038/s41586-021-03493-4
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33845483
Print-ISSN:
0028-0836
TUM Institution:
Institut für Virologie ; Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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