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Title:

Conformation-Specific Inhibitory Anti-MMP-7 Monoclonal Antibody Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Chemotherapeutic Cell Kill.

Document type:
Article; Journal Article
Author(s):
Mohan, Vishnu; Gaffney, Jean P; Solomonov, Inna; Levin, Maxim; Klepfish, Mordehay; Akbareian, Sophia; Grünwald, Barbara; Dym, Orly; Eisenstein, Miriam; Yu, Kenneth H; Kelsen, David P; Krüger, Achim; Edwards, Dylan R; Sagi, Irit
Abstract:
Matrix metalloproteases (MMPs) undergo post-translational modifications including pro-domain shedding. The activated forms of these enzymes are effective drug targets, but generating potent biological inhibitors against them remains challenging. We report the generation of anti-MMP-7 inhibitory monoclonal antibody (GSM-192), using an alternating immunization strategy with an active site mimicry antigen and the activated enzyme. Our protocol yielded highly selective anti-MMP-7 monoclonal antibody...     »
Journal title abbreviation:
Cancers (Basel)
Year:
2021
Journal volume:
13
Journal issue:
7
Fulltext / DOI:
doi:10.3390/cancers13071679
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33918254
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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