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Title:

TIMP1 expression underlies sex disparity in liver metastasis and survival in pancreatic cancer.

Document type:
Journal Article
Author(s):
Hermann, Chris D; Schoeps, Benjamin; Eckfeld, Celina; Munkhbaatar, Enkhtsetseg; Kniep, Lukas; Prokopchuk, Olga; Wirges, Nils; Steiger, Katja; Häußler, Daniel; Knolle, Percy; Poulton, Emily; Khokha, Rama; Grünwald, Barbara T; Demir, Ihsan Ekin; Krüger, Achim
Abstract:
Sex disparity in cancer is so far inadequately considered, and components of its basis are rather unknown. We reveal that male versus female pancreatic cancer (PC) patients and mice show shortened survival, more frequent liver metastasis, and elevated hepatic metastasis-promoting gene expression. Tissue inhibitor of metalloproteinases 1 (TIMP1) was the secreted factor with the strongest male-biased expression in patient-derived pancreatic tumors. Male-specific up-regulation of systemic TIMP1 was...     »
Journal title abbreviation:
J Exp Med
Year:
2021
Journal volume:
218
Journal issue:
11
Fulltext / DOI:
doi:10.1084/jem.20210911
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34533565
Print-ISSN:
0022-1007
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Chirurgie; Roman Herzog Comprehensive Cancer Center
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