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Title:

Uncovering the molecular identity of cardiosphere-derived cells (CDCs) by single-cell RNA sequencing.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kogan, Palgit-S; Wirth, Felix; Tomar, Archana; Darr, Jonatan; Teperino, Raffaele; Lahm, Harald; Dreßen, Martina; Puluca, Nazan; Zhang, Zhong; Neb, Irina; Beck, Nicole; Luzius, Tatjana; de la Osa de la Rosa, Luis; Gärtner, Kathrin; Hüls, Corinna; Zeidler, Reinhard; Ramanujam, Deepak; Engelhardt, Stefan; Wenk, Catharina; Holdt, Lesca M; Mononen, Mimmi; Sahara, Makoto; Cleuziou, Julie; Hörer, Jürgen; Lange, Rüdiger; Krane, Markus; Doppler, Stefanie A
Abstract:
Cardiosphere-derived cells (CDCs) generated from human cardiac biopsies have been shown to have disease-modifying bioactivity in clinical trials. Paradoxically, CDCs' cellular origin in the heart remains elusive. We studied the molecular identity of CDCs using single-cell RNA sequencing (sc-RNAseq) in comparison to cardiac non-myocyte and non-hematopoietic cells (cardiac fibroblasts/CFs, smooth muscle cells/SMCs and endothelial cells/ECs). We identified CDCs as a distinct and mitochondria-rich c...     »
Journal title abbreviation:
Basic Res Cardiol
Year:
2022
Journal volume:
117
Journal issue:
1
Fulltext / DOI:
doi:10.1007/s00395-022-00913-y
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35258704
Print-ISSN:
0300-8428
TUM Institution:
599; Institut für Pharmakologie und Toxikologie (Prof. Engelhardt); Klinik für Chirurgie angeborener Herzfehler und Kinderherzchirurgie (DHM) (Prof. Hörer); Klinik für Herz- und Gefäßchirurgie (DHM) (Prof. Lange)
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